Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease
Identifieur interne : 000434 ( Main/Exploration ); précédent : 000433; suivant : 000435Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinsons disease
Auteurs : Antonella Conte [Italie] ; Nicola Modugno [Italie] ; Francesco Lena [Italie] ; Sabrina Dispenza [Italie] ; Barbara Gandolfi [Italie] ; Ennio Iezzi [Italie] ; Giovanni Fabbrini [Italie] ; Alfredo Berardelli [Italie]Source :
- Brain [ 0006-8950 ] ; 2010-09.
Abstract
Whereas numerous studies document the effects of dopamine medication and deep brain stimulation on motor function in patients with Parkinsons disease, few have investigated deep brain stimulation-induced changes in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.
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DOI: 10.1093/brain/awq191
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in sensory functions. In this study of 13 patients with Parkinsons disease, we tested the effects of deep brain stimulation on the somatosensory temporal discrimination threshold. To investigate whether deep brain stimulation and dopaminergic medication induce similar changes in somatosensory discrimination, somatosensory temporal discrimination threshold values were acquired under four experimental conditions: (i) medication ON/deep brain stimulation on; (ii) medication ON/deep brain stimulation off; (iii) medication OFF/deep brain stimulation on; and (iv) medication OFF/deep brain stimulation off. Patients also underwent clinical and neuropsychological evaluations during each experimental session. Somatosensory temporal discrimination threshold values obtained in patients were compared with 13 age-matched healthy subjects. Somatosensory temporal discrimination threshold values were significantly higher in patients than in healthy subjects. In patients, somatosensory temporal discrimination threshold values were significantly lower when patients were studied in medication ON than in medication OFF conditions. Somatosensory temporal discrimination threshold values differed significantly between deep brain stimulation on and deep brain stimulation off conditions only when the patients were studied in the medication ON condition and were higher in the deep brain stimulation on/medication ON than in the deep brain stimulation off/medication ON condition. Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with Parkinsons disease. Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Conte, Antonella" sort="Conte, Antonella" uniqKey="Conte A" first="Antonella" last="Conte">Antonella Conte</name></region><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Dispenza, Sabrina" sort="Dispenza, Sabrina" uniqKey="Dispenza S" first="Sabrina" last="Dispenza">Sabrina Dispenza</name><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><name sortKey="Gandolfi, Barbara" sort="Gandolfi, Barbara" uniqKey="Gandolfi B" first="Barbara" last="Gandolfi">Barbara Gandolfi</name><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><name sortKey="Lena, Francesco" sort="Lena, Francesco" uniqKey="Lena F" first="Francesco" last="Lena">Francesco Lena</name><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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